APFIVE Trinucleotide Repeat Expansion and Disease Onset
A genetic disorder is caused by a trinucleotide repeat expansion. As the number of repeats increases across generations, the age of disease onset decreases. Which property of nucleic acid structure best explains this phenomenon?
A
Altered 3D conformations affecting gene expression
B
Higher phosphate content improving energy transfer
C
Increased molecular weight enhancing replication speed
D
Greater number of hydrogen bonds increasing stability
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