Transport proteins in facilitated diffusion actively pump molecules against their concentration gradient, requiring ATP, unlike passive simple diffusion.

Transport proteins in facilitated diffusion and simple diffusion both require energy input, but facilitated diffusion is more specific for certain molecules.

In facilitated diffusion, transport proteins only allow small, nonpolar molecules to pass, while simple diffusion permits all types of molecules to cross the membrane.

Transport proteins in facilitated diffusion provide specific channels or carriers for molecules, requiring no energy input, and allow larger or charged molecules to pass, unlike simple diffusion.