KDEL Retention Signal Function
A cell line is genetically engineered to remove the KDEL retention signal from proteins that are normally retained in the endoplasmic reticulum (ER). Which of the following is the most likely observation?
A
Mitochondrial proteins accumulating in the cytosol
B
Nuclear proteins being exported to the cytoplasm
C
ER-resident enzymes appearing in the Golgi apparatus
D
Peroxisomal enzymes localizing to lysosomes
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