APFIVE KDEL Retention Signal Function
A cell line is genetically engineered to remove the KDEL retention signal from proteins that are normally retained in the endoplasmic reticulum (ER). Which of the following is the most likely observation?
A
Peroxisomal enzymes localizing to lysosomes
B
ER-resident enzymes appearing in the Golgi apparatus
C
Nuclear proteins being exported to the cytoplasm
D
Mitochondrial proteins accumulating in the cytosol
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