APFIVE Retrograde Transport of Phospholipids
Radioactively labeled phospholipids are incorporated into the plasma membrane of a cell by vesicle fusion. After some time, these labeled phospholipids are detected in the endoplasmic reticulum (ER). Which of the following sequences of membrane transport events best accounts for this observation?
A
Receptor-mediated endocytosis, then direct transfer to the ER
B
Exocytosis, then endocytosis, followed by retrograde transport
C
Phagocytosis, then vesicle budding to enter the ER
D
Active transport into the cell, then facilitated diffusion to the ER
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