APFIVE In an experiment investigating a G-protein-linked receptor, a researcher adds a known ligand but observes no subsequent increase in intracellular cAMP levels. Based on this finding, the researcher concludes that the receptor’s signaling pathway does not involve cAMP as a second messenger. Which of the following identifies a potential flaw in this conclusion?
The pathway might involve cAMP, but the experimental conditions did not allow for its accumulation or detection.
The researcher’s conclusion was correct; the receptor does not use cAMP as a second messenger.
cAMP is not a second messenger in any cell signaling pathways; it serves a different cellular function.
G-protein-linked receptors cannot use cAMP as a second messenger; only enzyme-linked receptors can.
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