APFIVE Anaphase-Promoting Complex Function
A mutation in the APC/C (anaphase-promoting complex/cyclosome) causes cells to arrest at metaphase. Which of the following best explains the role of APC/C in ensuring genome integrity during mitosis?
A
It condenses chromatin into visible chromosomes
B
It triggers degradation of securin, allowing separase to cleave cohesins
C
It directly repairs DNA damage before chromosome segregation
D
It synthesizes the proteins needed for spindle formation
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