Anaphase-Promoting Complex Function
Cells with a mutation in the anaphase-promoting complex/cyclosome (APC/C) often arrest in metaphase. Which of the following best describes the role of the APC/C in maintaining genomic integrity during mitosis?
A
It synthesizes the proteins needed for spindle formation
B
It triggers degradation of securin, allowing separase to cleave cohesins
C
It directly repairs DNA damage before chromosome segregation
D
It condenses chromatin into visible chromosomes
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