BMP4 Concentration and Cell Differentiation
In an experiment on a developing embryo, researchers observed that applying low concentrations of the BMP4 protein induced mesoderm formation, while applying high concentrations induced epidermis formation. Which of the following cellular mechanisms best explains this differential response to BMP4?
A
Concentration-dependent activation of different transcription factors
B
Tissue-specific differences in BMP4 receptor structure
C
Competitive inhibition by other growth factors
D
BMP4 degradation into different signaling molecules
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