APFIVE JAK-STAT Pathway Transcription Factor Mutation
A researcher introduces a point mutation that alters the phosphorylation site on a transcription factor in the JAK-STAT pathway. Which of the following best predicts the effect on signal transduction?
A
Increased receptor sensitivity to cytokines
B
Accelerated degradation of the cytokine ligand
C
Enhanced binding of the transcription factor to DNA
D
Prevention of transcription factor dimerization and nuclear entry
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