JAK-STAT Pathway Transcription Factor Mutation
A point mutation disrupts the phosphorylation site of a transcription factor in the JAK-STAT signaling pathway. Which of the following best predicts the resulting effect on signal transduction?
A
Increased receptor sensitivity to cytokines
B
Enhanced binding of the transcription factor to DNA
C
Prevention of transcription factor dimerization and nuclear entry
D
Accelerated degradation of the cytokine ligand
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