Non-Genomic Estrogen Signaling
After treating cells with estrogen, researchers measure the phosphorylation of various proteins. Which observation would provide the best evidence that estrogen activates non-genomic signaling pathways in addition to its classical genomic pathway?
A
Increased mRNA levels of target genes after 2 hours
B
Synthesis of new estrogen receptor proteins
C
Nuclear translocation of estrogen receptors
D
Rapid phosphorylation of MAP kinases within minutes
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