APFIVE Non-Genomic Estrogen Signaling
In an experiment, cells were treated with estrogen and the phosphorylation states of various proteins were measured. Which observation would suggest that estrogen is activating non-genomic signaling pathways in addition to its classical genomic pathway?
A
Synthesis of new estrogen receptor proteins
B
Increased mRNA levels of target genes after 2 hours
C
Rapid phosphorylation of MAP kinases within minutes
D
Nuclear translocation of estrogen receptors
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