APFIVE Ras Protein Mutation and Cell Signaling
A patient has a genetic condition characterized by excessive cell proliferation in certain tissues. Genetic analysis reveals a mutation in the GTPase domain of a Ras protein that prevents GTP hydrolysis. How does this mutation most likely affect cell signaling?
A
Ras cannot bind to GTP, blocking all downstream signaling
B
Ras degrades more rapidly, reducing signal duration
C
Ras binds to inhibitory proteins more effectively
D
Ras remains locked in its active state, continuously signaling
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