APFIVE Role of Topoisomerase II in Mitosis
When cells are treated with a chemical that inhibits topoisomerase II, they arrest in mitosis. Although the chromosomes condense, they fail to separate. Which of the following best explains the essential role of topoisomerase II in successful mitosis?
A
It resolves DNA catenations that would prevent chromosome separation
B
It phosphorylates histone proteins to trigger condensation
C
It initiates DNA replication at origins during S phase
D
It activates cyclin-dependent kinases at the G2 checkpoint
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