APFIVE Thyroid Hormone Receptor Mutation
A genetic mutation results in a thyroid hormone receptor that can bind DNA but cannot recruit coactivator proteins. Which of the following would be the most likely consequence of this mutation?
A
Inhibition of target gene expression even in the presence of thyroid hormones
B
Increased degradation of thyroid hormones in the bloodstream
C
Constitutive activation of target genes without hormone binding
D
Normal regulation of gene expression with decreased sensitivity
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