Thyroid Hormone Receptor Mutation
A genetic mutation produces a thyroid hormone receptor that can bind to DNA but is unable to recruit coactivator proteins. Which of the following describes the most likely consequence of this mutation?
A
Normal regulation of gene expression with decreased sensitivity
B
Inhibition of target gene expression even in the presence of thyroid hormones
C
Increased degradation of thyroid hormones in the bloodstream
D
Constitutive activation of target genes without hormone binding
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