Meiotic Nondisjunction and Aneuploidy
Which of the following best provides evidence that nondisjunction, a cause of aneuploidies such as Down syndrome, can occur during either anaphase I or anaphase II of meiosis?
Analyses of cell division reveal that errors during both anaphase I and anaphase II can lead to gametes with abnormal numbers of chromosomes, as seen in cases where an extra copy of chromosome 21 is present.
Fluorescent in situ hybridization (FISH) consistently shows normal diploid numbers in gametes, which would rule out the occurrence of nondisjunction.
Microscopic imaging during interphase occasionally shows misaligned chromosomes, but this does not provide information about the specific stages where nondisjunction occurs.
Protein assays indicating abnormal cohesin complex levels suggest potential segregation errors, yet they do not specifically pinpoint nondisjunction during anaphase I or II.
Question Leaderboard
| Rank | |||||
|---|---|---|---|---|---|
| #1 | shenhaoxin2008 | 1 | 1 | 0m 00s | 100 |
| #2 | thelasthuayra12072009 | 1 | 1 | 0m 00s | 100 |
| #3 | shaurya.n.pandit | 1 | 1 | 0m 00s | 100 |
| #4 | songjiseok5 | 1 | 1 | 0m 00s | 100 |
| #5 | neil.sethi9 | 1 | 1 | 0m 00s | 100 |
| #6 | hamnah.crystal | 1 | 1 | 0m 00s | 100 |
| #7 | mahadevsmenon1910 | 1 | 1 | 0m 00s | 100 |
| #8 | gabrielwfidel | 1 | 1 | 0m 15s | 85 |
| #9 | celinecomiaa | 0 | 1 | 0m 00s | -10 |
| #10 | eman.utinfo | 1 | 1 | 2m 11s | -31 |