APFIVE Nonsense Mutation and mRNA Stability
A nonsense mutation is introduced near the start of a gene’s coding sequence. Subsequent analysis shows that the resulting mRNA is significantly shorter than the wild-type mRNA, and no protein is produced. Which of the following is the most likely explanation for these observations?
A
The nonsense mutation altered the mRNA’s poly(A) tail, preventing translation.
B
The nonsense mutation introduced a premature stop codon, terminating translation early.
C
The mutation interfered with the ribosome’s ability to bind to the mRNA.
D
The mutation destabilized the mRNA, leading to its rapid degradation.
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