Chromosomal Duplication and Gene Regulation
A duplication mutation is induced in a gene, but this leads to a decrease in the gene’s expression level rather than the expected increase. Which of the following provides the most likely explanation for this observation?
A
The duplicated gene was inserted in a region of heterochromatin, silencing its expression.
B
The mutation caused a frameshift, altering the reading frame of the gene.
C
The duplicated gene was recognized as foreign DNA and silenced by the cell.
D
The duplication mutation disrupted regulatory elements controlling the gene’s expression.
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