Increasing nucleotide concentration indefinitely will always result in reaction rates that surpass $$V_{max}$$ due to substrate excess.

When the substrate concentration is significantly larger than $$K_m$$, the reaction rate saturates and approaches $$V_{max}$$.

In practical experiments, nucleotide concentrations are maintained at levels that bring the reaction rate close to, but not exceeding, $$V_{max}$$.

The Michaelis-Menten model indicates that at high substrate concentrations, further increases do not significantly affect the reaction rate.