MicroRNA Gene Regulation Failure
A researcher synthesizes a microRNA (miRNA) that is perfectly complementary to a target mRNA. When introduced into cells, the miRNA fails to affect the expression of the target gene. Which of the following best explains this lack of gene regulation?
A
The synthesized miRNA was rapidly degraded by cellular RNases.
B
miRNAs typically regulate gene expression by imperfect base pairing, not perfect complementarity.
C
The target mRNA has a secondary structure that prevents miRNA binding.
D
The miRNA was not processed by the Dicer enzyme, preventing its incorporation into RISC.
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