APFIVE miRNA Regulation of Tumor Growth
In an attempt to study the role of microRNAs (miRNAs) in cancer, a researcher overexpresses a specific miRNA in a cancer cell line. They predict that this will suppress tumor growth. However, the tumor growth rate increases. What mistake did the researcher make in their experimental design?
A
They assumed that overexpression of any miRNA would suppress tumor growth.
B
They overlooked the possibility that the miRNA is naturally downregulated in cancer.
C
They did not consider that the miRNA might target tumor suppressor genes instead of oncogenes.
D
They used a cell line that is resistant to miRNA-mediated regulation.
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