miRNA Regulation of Tumor Growth
A researcher overexpresses a specific microRNA (miRNA) in a cancer cell line, hypothesizing it will suppress tumor growth. However, the experiment results in an increased tumor growth rate. Which of the following best explains this outcome?
A
They overlooked the possibility that the miRNA is naturally downregulated in cancer.
B
They assumed that overexpression of any miRNA would suppress tumor growth.
C
They did not consider that the miRNA might target tumor suppressor genes instead of oncogenes.
D
They used a cell line that is resistant to miRNA-mediated regulation.
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