APFIVE Nonsense Mutation and mRNA Stability
In an experiment to study the effects of mutations on protein function, a researcher introduces a nonsense mutation at the beginning of a gene. The resulting mRNA is significantly shorter than expected, and no protein is produced. What is the most likely explanation for the absence of protein production?
A
The mutation interfered with the ribosome’s ability to bind to the mRNA.
B
The nonsense mutation altered the mRNA’s poly(A) tail, preventing translation.
C
The nonsense mutation introduced a premature stop codon, terminating translation early.
D
The mutation destabilized the mRNA, leading to its rapid degradation.
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