APFIVE Telomerase Gene Deletion and Aging
A researcher investigating the role of telomeres in aging uses a CRISPR-Cas9 system to remove the telomerase gene from mouse embryonic stem cells. They predict that these modified mice will show premature aging symptoms. However, the mice develop normally and show no signs of premature aging. What mistake did the researcher make in their hypothesis?
A
They did not account for compensatory mechanisms that might maintain telomere length.
B
They used an incorrect guide RNA sequence in the CRISPR-Cas9 system.
C
They overlooked the possibility that mice have a different aging mechanism.
D
They assumed that telomerase is the only enzyme that affects telomere length.
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