Telomerase Gene Deletion and Aging
A researcher hypothesizes that deleting the telomerase gene from mouse embryonic stem cells will cause the resulting mice to show signs of premature aging. Contrary to this prediction, the mice develop normally. Which of the following best explains a potential flaw in the researcher’s hypothesis?
A
They assumed that telomerase is the only enzyme that affects telomere length.
B
They used an incorrect guide RNA sequence in the CRISPR-Cas9 system.
C
They overlooked the possibility that mice have a different aging mechanism.
D
They did not account for compensatory mechanisms that might maintain telomere length.
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