APFIVE Translation Termination Failure
A rare genetic disorder is characterized by the synthesis of proteins with additional amino acids at their C-terminus. Genetic analysis confirms that the stop codons in the corresponding genes are intact. Which of the following best explains this molecular phenomenon?
A
Mutation in a release factor that recognizes stop codons
B
Overexpression of suppressor tRNAs
C
Defective RNA polymerase adding extra nucleotides
D
Abnormal ribosome structure affecting the A site
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