Limitation of a Single-Sample Study
A researcher claims a new medication reduces average cholesterol levels. In a study, 25 patients were treated, resulting in a mean cholesterol reduction of 12 mg/dL with a standard deviation of 15 mg/dL. The corresponding test statistic is t = 4.00 with a p-value of 0.0003. Which of the following represents the most significant limitation of the study’s design?
A
The sample size is too large to detect meaningful effects.
B
The p-value is too small to be meaningful.
C
The study lacks a control group for comparison.
D
The standard deviation indicates the treatment is ineffective.
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